He was born February 25, 1979, in Pickerington Ohio to Randy and Renee Shaffer.
He was a medical student at Ohio State University.March 31, 2006, Shaffer went out with friends to celebrate the beginning of spring break.
They went to the Ugly Tuna bar.
Later they separated and his friends assumed he had gone home.
Later they separated and his friends assumed he had gone home.
A security camera near the entrance to a bar recorded him briefly talking to two women just before 2 a.m., April 1, and then apparently re-entering the bar.
No evidence and no footage has ever been found of Brain leaving the bar.
That was the last time he was seen.
On Monday morning he missed the flight to Miami he and his girlfriend had scheduled long before.
That is when he was reported missing.
Some interest and suspicion has been directed at a friend of Shaffer's who accompanied him that night and has declined to take lie detector tests.
Foul play has been highly suspected.
Some suggest that he might have been a victim of the Smiley Face Serial Killer.
Brian's girlfriend called Brian's phone every evening before going to bed for a long time after the disappearance.
Usually it went to voicemail, but one night in September it rang three times.
"I kept calling it to hear it purely because it was one of the best sounds I have ever heard, even if no one picked up", she wrote on her MySpace page.
Brian's wireless provider, said what Brain's girlfriend heard may have been due to a computer glitch.
A ping from the phone was detected at a cell tower in Hilliard, 14 miles northwest of Columbus.
His vanishing act remains unsolved.
His vanishing act remains unsolved.
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